- Product Description
-
- Commodity name: Hot-melt extrusion technology
- 英文: Hot melt extrusion technology
By leveraging the principles of supramolecular chemistry to enhance the interactions between drugs and carrier materials, and through the rational selection and optimized formulation of these carriers, the drug can be stably maintained in a glassy state for an extended period. Upon dissolution, no energy is required to overcome lattice energy, resulting in higher solubility and faster dissolution rates, thereby significantly improving the bioavailability of poorly soluble drugs. Nanocrystalline curcumin prepared using this process exhibits rapid dissolution, markedly enhanced bioavailability (approximately 34-fold increase), excellent stability, strong safety, and prolonged therapeutic efficacy, and has already been procured and applied by well-known domestic enterprises such as GuaiBao.
Currently, several human-use hot-melt extrusion formulations are already on the market.Product Name
Manufacturer
Medication
Purpose of Use
Ozurdex®
Allergan (USA)
Dexamethasone
Diabetic Macular Edema
Kaletra®
Abbott (United States) Already Abbott
Lopinavir and Ritonavir
Solubilization
Covera-HS®
Pfizer (United States)
Verapamil Hydrochloride
Sustained release
Zithromax®
Azithromycin
Mask the taste
Noxafil®
Merck (United States) MeR tk
Posaconazole
Solubilization/Enteric Coating
NuvaRing®
Norethisterone/ethinyl estradiol
Contraception
Eucreas®
Novartis (Switzerland)
Vildagliptin/Metformin
Melt Granulation
Adalat SL®
Bayer (Germany)
Nifedipine
Controlled-release
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